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Cilnidipine

Cilnidipine
Cilnidipine
Product Code : 03
Brand Name : Cilnidipine
Product Description

Our vision is to become a well-known global player in the healthcare and pharmaceutical sector by offering a premium range of Cilnidipine. These drugs improve baroreflex sensitivity and reduce Serum uric acid. Our Cilnidipine is processed from best quality natural ingredients and compounds at our hygienic facility, in accordance with international quality standards. We adhere to the parameters of the national and international quality standards to provide the clients with utmost satisfaction in terms of quality.

Features:

  • No side effect
  • Safe to consume
  • Highly effective

Cilnidipine

IUPAC NAME: O3-(2-methoxyethyl) O5-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine- 3,5-dicarboxylate.

CAS Number : 132203-70-4

Therapeutic Category: Hypertension.

Innovator: Fuji Viscera Pharmaceutical Company, Japan and Ajinomoto, Japan

Indication : Oral Hypertension

Dosage: Adult: 5-10 mg once daily, increase to 20 mg once daily if necessary

Class: Calcium Antagonists

Introduction:

“CILNIDIPINE  is Calcium Channel Blocker. Is a dual blocker of L-type voltage-gated calcium channels in vascular smooth muscle and N-type calcium channels in sympathetic nerve terminals that supply blood vessels. This is new generation product which is much more advanced than Amlodipine series

Mechanism of Action:

Cilnidipine is a dihydropyridine calcium-channel blocker. It inhibits cellular influx of calcium, thus causing vasodilatation. It has greater selectivity for vascular smooth muscle. It has little or no action at the SA or AV nodes and -ve inotropic activity is rarely seen at therapeutic doses

CILNIDIPINE ADVANTAGES OVER AMLODIPINE:


  • One of the main advantage of CILNIDIPINE is it reduces the incidence of Pedal Edema unlike Amlodipine.

  • CILNIDIPINE due to its blocking action at N-type calcium channel dilates both arteriole & venules as a result the pressure in the capillary bed is reduces. The accumulated fluid in the tissues flows back to veins & thus Cilnidipine minimizes the incidence of pedal edema. L-type calcium channel blocker (Amlodipine) dilates the only arterioles & not the venules, hence blood pressure increases in the capillary bed and are thought to cause leg edema.

  • CILNIDIPINE has similar blood pressure lowering efficacy as compared to amlodipine

  • One of the distinct property of CILNIDIPINE from amlodipine is that it does not cause reflex tachycardia.

Hence Cilnidipine compels to rethink on Hypertension Management:

  • Improves baroreflex sensitivity

  • Improves NO availability

  • Ensures Antiproliferative effect

  • Inhibition of platelet activity

  • Exerts Antiarrhythmic effect

  • Reduction in Serum uric acid

INDIA BRAND: CILCAR 5mg/10mg/20mg