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Established in the year 1950, we have emerged as the most trusted manufacturer and supplier of Sitagliptin. Available in forms such as tablets & capsule, these drugs are helpful in the treatment of diabetes and control blood glucose level. In order to process Sitagliptin, we use top quality compounds and modern technology at our hygienic facility. Our clients can avail these drugs from us at a reasonable price.
IUPAC Name : (R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
CAS Number : 486460-32-6
Innovator : It was developed, and is marketed, by Merck & Co
Therapeutic Category: Antidiabetic Drug
Indication : For treatment of diabetes mellitus type
Dosage: 25mg, 50 mg , 100 mg .
Class: Ipeptidyl peptidase-4 (DPP-4) inhibitor class
This enzyme-inhibiting drug is used either alone or in combination with other oral antihyperglycemic agents (such as metformin or a thiazolidinedione) for treatment of diabetes mellitus type 2. The benefit of this medicine is its fewer side effects (e.g., less hypoglycemia, less weight gain) in the control of blood glucose values. While safety is its advantage, efficacy is often challenged as it is often recommended to be combined with other agents such as metformin.
Mechanism of Action:
Sitagliptin works to competitively inhibit the enzyme dipeptidyl peptidase 4 (DPP-4). This enzyme breaks down the incretins GLP-1 and GIP, gastrointestinal hormones released in response to a meal. By preventing GLP-1 and GIP inactivation, they are able to increase the secretion of insulin and suppress the release of glucagon by the alpha cells of the pancreas. This drives blood glucose levels towards normal. As the blood glucose level approaches normal, the amounts of insulin released and glucagon suppressed diminishes, thus tending to prevent an "overshoot" and subsequent low blood sugar (hypoglycemia) which is seen with some other oral hypoglycemic agents
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