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TENELIGLIPTIN

TENELIGLIPTIN
TENELIGLIPTIN
Product Code : 29
Brand Name : TENELIGLIPTIN
Product Description

Being a reputed manufacturer and exporter, we are certain to offer our clients an appreciable range of TENELIGLIPTIN.

 IUPAC NAME:

 {(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl}(1,3-thiazolidin-3-yl) methanone

 

CAS Number760937-92-6


Molecular Formula: C22H30N6OS

 

Therapeutic Category: Antidiabetic

 

Innovator:

Mitsubishi Tanabe Pharma and launched in September 2012 by both Mitsubishi Tanabe Pharma and Daiichi Sankyo in Japan


Dosage:

In adults, 20 mg of Teneligliptin may be orally administered once daily. If this dosage is insufficient, the dosage is increased to 40 mg once daily.

 

Class: Gliptin

                                                                                                                            

Introduction:

 

     Teneligliptin (Trade name Tenelia) is a pharmaceutical drug for the treatment of type 2 diabetes mellitus. It belongs to the class of anti-diabetic drugs known as dipeptidyl peptidase-4 inhibitors or "gliptins"

 

     Teneligliptin has unique J shaped or anchor locked domain structure because of which it has more potent inhibition of DPP 4 enzyme as compared to Sitagliptin and Vildagliptin


      Teneligliptin significantly controls glycemic parameters with safety. No dose adjustment is required in renally impaired patients

 

Mechanism of Action:

 

      Teneligliptin for the treatment of patients with Type 2 diabetes mellitus (T2DM). T2DM is a chronic disease characterized by hyperglycemia due to decreased secretion of insulin, the hormone that controls blood sugar levels, and resistance to the effects of insulin.

      Teneligliptin consists of a considerably rigid J-shaped structure formed by five rings, four of which are directly connected to DPP -4 which provides strongest binding to DPP -4 enzymes as compared to other gliptins

      Anchor lock domain, which binds to the S2 extensive subsite, increased the activity by 1500 -fold over the corresponding fragment that binds to S1 & S2 only.

 

Teneligliptin  Advantages:

Teneligliptin is well tolerated, safe, and significantly improves glycemic control in diabetic patients with ESRD. 

Teneligliptin 20 mg is probably stronger than Vildagliptin 50 mg for dialysis patientsTeneligliptin: a novel DPP-4 inhibitor for hemodialysis patients with type 2 diabetes.
Teneligliptin significantly improves the glycemic states in Diabetic ESRD patients

Teneligliptin exhibits beneficial effects on both oxidative stress and endothelial function in Japanese patients with type 2 diabetes and CKD

Improves glycemic states in patients switching from conventional Oral Anti-Diabetic drugs.



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Mr. Saumi Thakar (General Manager)
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